Rickettsia Symptoms

Let us begin with understanding what Rickettsia is and what are the means by which it can infect us before getting to Rickettsia symptoms. A Rickettsia is a small, Gram-negative, aerobic, coccobacillus (a type of rod-shaped bacterium), that is an obligate intracellular parasite of the eucaryotic cells (cells having a nucleus which carry genetic matter). These bacteria may reside in the cytoplasm as well as within the nucleus of the cell invaded by them. They reproduce via binary fission and metabolize host-derived glutamae through aerobic respiration and citric acid cycle. Common insects like ticks, mites, etc. and lice (both body and head lice) are major carriers of Rickettsia.

Symptoms of Rickettsia

The initial symptoms include fever, headache, myalgia, gastroenteric dysfunctions, inflammation of the lymph nodes, malaise, etc. A rash often appears after a few days of the onset of fever, the appearance of which depends upon the type of the disease. For instance, Rickettsia problems like scrub typhus, tick typhus and Rickettsialpox are symptomized by appearance of lesions on skin at the sites of the insect bites. However, severe cases of Rickettsia infection can exhibit complicated symptoms such as restricted respiratory sufficiency, neurological disturbances, renal failure, gastrointestinal hemorrhage and opportunistic viral, and fungal infection. Rickettsia is a genus of bacteria that falls under the bacterial family Rickettsiaceae of the order Rickettsiales. The Rickettsiae that infect humans can be sub divided into 3 distinct groups:

1. Spotted Fever Group
2. Epidemic Typhus Group
3. Scrub Typhus Group

Spotted Fever Group of bacteria are responsible for causing diseases like Rocky Mountain Spotted Fever, Boutonneuse fever, Rickettsialpox, Siberian tick typhus, Oriental spotted fever and Australian tick typhus. This group can be found distributed all over the Western hemisphere, Mediterranean Nations, Africa, India and Southwest Asia including Mongolia, China and Japan, USA, former Soviet countries, Siberia and Australia. The primary carriers of this group of bacteria are ticks and Rickettsiae belonging to this group attack human vascular endothelial cells, eliciting inflammatory response as one of the primary Rickettsia symptoms. The Rickettsiae belonging to the Spotted Fever Group are:

• R. rickettsii
• R. akari
• R. conorii
• R. sibirica
• R. australis
• R. japonica

An interesting observation about this group of organisms is that they exist on in all continents except Antarctica. Also, it is unusual for these bacteria to occur in winter.

Epidemic Typhus Group of Rickettsiae are primarily louse-born, sometimes flea-born, and infect the human vascular endothelial cells, causing widespread vasculitis. As opposed to the Spotted Fever Group of Rickettsiae, this group of organisms mainly occur in winter. Since it is carried by lice, it spreads and manifests under conditions of crowd and poor sanitation. Rickettsiae belonging to this group are:

• R. prowazekii
• R. typhi
• R. felis

Rickettsia symptoms induced by this group of Rickettsiae are similar to the symptoms of murine typhus.

Scrub Typhus Group consists of only one microorganism, the R. tsutsugamushi or the Orientia tsutsugamushi. It is transmitted to humans via the bite of trombiculid mites. Scrub typhus is prevalent throughout much of Asia and Australia. It shares the dominant symptom of widespread microvascular damage with Spotted Fever and Epidemic Typhus.

All Rickettsia problems begin with the bite of an arthropod carrier or through cutaneous abrasions contaminated by flea/louse excreta. Rickettsia infection begins with introduction of the Rickettsiae into the skin. These organisms enter the dermal cells and spread intracellularly with endothelial cell-to-cell spread. The most prominent patho-physiological impact is, increased vascular permeability with consequent abnormal water retention, loss of blood volume, abnormally low levels of albumin in blood serum, reduced osmotic pressure, and unnaturally low blood pressure. These may lead to fatal consequences and may result in pulmonary edema and adult respiratory distress syndrome, shock or even acute tubular necrosis.

In case you experience any of the aforementioned symptoms, antibiotics like chlorampenicol and tetracycline are effective cures. Doxycycline, a semi synthetic tetracycline, is a sure shot cure for Rocky Mountain Spotted fever. However, it is advisable to consult a registered medical practitioner before trying out any medication on yourself. Prevention is always better than cure though! The best way to prevent Rickettsia infection and avoid the above mentioned symptoms is to maintain personal hygiene, avoid crowded and dirty places as much as possible, and if at all going to such places, wear light-colored clothes so that you can see if you got any fleas/ticks/mites/lice on you. Also, wearing clothes which cover the entire body when visiting possible bug prone areas may help keep the lice and ticks out. Stay clean, stay healthy and stay "de-bugged"!

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